Research

Recent Alzheimer Disease Publications

Alier K, Ma L, Yang J, Westaway D, Jhamandas JH. "Aβ Inhibition of Ionic Conductance in Mouse Basal Forebrain Neurons Is Dependent upon the Cellular Prion Protein PrPC." J Neurosci. 2011 Nov 9;31(45):16292-7.

Amtul Z, Keet M, Wang L, Merrifield P, Westaway D, Rozmahel RF. "DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?" PLoS One. 2011;6(9):e24094. Epub 2011 Sep 8.

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. "Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis." Autophagy. 2011 Jul;7(7):788-9. Epub 2011 Jul 1.

Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D. "Actions of β-amyloid protein on human neurons are expressed through the amylin receptor." Am J Pathol. 2011 Jan;178(1):140-9. Epub 2010 Dec 23.

Amtul Z, Wang L, Westaway D, Rozmahel RF. "Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease" Neuroscience. 2010 Aug 25;169(2):781-6. Epub 2010 May 21.

Kuzyk A, Kastyak M, Agrawal V, Gallant M, Sivakumar G, Rak M, Del Bigio MR, Westaway D, Julian R, Gough KM. "Association between amyloid plaque, lipid, and creatine in hippocampus of TgCRND8 mouse model for Alzheimer disease " J Biol Chem. 2010 Aug 3.

Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S. "Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains" Glia 2010 Aug 15;58(11):1267-81.

Amritraj A, Rauw G, Baker GB, Kar S. "Leu(27) insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices" Neuroscience. 2010 Jul 24. [Epub ahead of print]

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. "Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations" Cell 2010 Jun 25;141(7):1146-58. Epub 2010 Jun 10.

Soong Ho Kim, Paul Fraser, David Westaway, Peter St George-Hyslop, Michelle Ehrlich, and Samuel Gandy " Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid Aβ42 from isolated intact nerve terminals" J. Neuroscience 2010, Mar 17;30(11):3870-5.

A. Amritaj, K. Peake, A. Kodam, C. Salio, A. Merighi, J. Vance, S. Kar "Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice" Am. J. Pathol 2009 Dec;175(6):2540-56.

Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. "Acute dosing of latrepirdine (DimebonTM), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo" Mol Neurodegener. 2009 Dec 17;4(1):51.

Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. "Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology" Mol Neurodegener. 2009 Oct 21;4:40.

Song MS, Rauw G, Baker GB, Kar S. "Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation" Eur J Neurosci. 2008 Nov;28(10):1989-2002.

Sasaki A, et al. “Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTau(P301L) ” Brain Res. 2008 Jun 12;1214:159-68.

Bai Y, et al. "The in vivo brain interactome of the amyloid precursor protein" Mol Cell Proteomics. 2008 Jan;7(1):15-34