Research

Recent Alzheimer Disease Publications

Soong Ho Kim, Paul Fraser, David Westaway, Peter St George-Hyslop, Michelle Ehrlich, and Samuel Gandy "Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid Aβ42 from isolated intact nerve terminals" J. Neuroscience 2010, In press

A. Amritaj, K. Peake, A. Kodam, C. Salio, A. Merighi, J. Vance, S. Kar "Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice" Am. J. Pathol 2009 Dec;175(6):2540-56.

Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. "Acute dosing of latrepirdine (DimebonTM), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo" Mol Neurodegener. 2009 Dec 17;4(1):51.

Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. "Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology" Mol Neurodegener. 2009 Oct 21;4:40.

Song MS, Rauw G, Baker GB, Kar S. "Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation" Eur J Neurosci. 2008 Nov;28(10):1989-2002.

Sasaki A, et al. “Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTau(P301L) ” Brain Res. 2008 Jun 12;1214:159-68.

Bai Y, et al. "The in vivo brain interactome of the amyloid precursor protein" Mol Cell Proteomics. 2008 Jan;7(1):15-34

Saavedra L, Mohamed A, Ma V, Kar S, de Chaves EP. "Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E" J Biol Chem. 2007 Dec 7;282(49):35722-32. Epub 2007 Oct 2.

Afkhami-Goli A, et al. "Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease" J Immunol. 2007 Oct 15;179(8):5493-503

Van Vickle GD, et al. "TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation" BioChemistry. 2007 Sep 11;46(36):10317-27.

Amritraj, A., et al. “Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP+PS1 transgenic mouse brains”. Neurobiology of Aging, 2007 June 9; 54-70

Hawkes C, Amritraj A, Macdonald RG, Jhamandas JH, Kar S. "Heterotrimeric G proteins and the single-transmembrane domain IGF-II/M6P receptor: functional interaction and relevance to cell signaling" Mol Neurobiol. 2007 Jun;35(3):329-45. Review.