Research

Recent Prion Publications

Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. "Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP Accumulation." PLoS Pathog. 2011 Nov;7(11):e1002391. Epub 2011 Nov 17.

Westaway D, Daude N, Wohlgemuth S, Harrison P. "The PrP-like proteins Shadoo and Doppel." Top Curr Chem. 2011;305:225-56.

Kang SG, Roh YM, Lau A, Westaway D, McKenzie D, Aiken J, Kim YS, Yoo HS. "Establishment and characterization of Prnp knockdown neuroblastoma cells using dual microRNA-mediated RNA interference." Prion. 2011 Apr-Jun;5(2):93-102. Epub 2011 Apr 1.

Wei X, Herbst A, Ma D, Aiken J, Li L."A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome." J Proteome Res. 2011 Jun 3;10(6):2687-702. Epub 2011 Apr 25.

Johnson CJ, McKenzie D, Pedersen JA, Aiken JM."Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission." J Toxicol Environ Health A. 2011;74(2-4):161-6.

Moody LR, Herbst AJ, Aiken JM."Upregulation of interferon-gamma-induced genes during prion infection." J Toxicol Environ Health A. 2011;74(2-4):146-53.

Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PS, Matsubara E, Shoji M. "Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy." J Neurosci Res. 2011 Apr;89(4):576-84. doi: 10.1002/jnr.22572. Epub 2011 Jan 13.

Wei, X., Herbst, A., Ma, D., Aiken, J., Li, L. "A Quantitative Proteomic Approach to Prion Disease Biomarker Research: Delving into the Glycoproteome." Journal of Proteome Research, April 6, 2011.

Sang-Gyun Kang, Yu-Mi Roh, Agnes Lau, David Westaway, Debbie McKenzie, Judd M. Aiken, Yong-Sun Kim and Han Sang Yoo. "Establishment and characterization of Prnp knock-down neuroblastoma cells using dual microRNA-mediated RNA interference." Prion 5(2), Apr 1, 2011.

Chad J. Johnson, Allen Herbst, Camilo Duque-Velasquez, Joshua P. Vanderloo, Phil Bochsler, Rick Chappell, Debbie McKenzie "Prion Protein Polymorphisms Affect Chronic Wasting Disease Progression " PLoS ONE 6(3): e17450. doi:10.1371/journal.pone.0017450 Mar 2011.

Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D. "Actions of β-amyloid protein on human neurons are expressed through the amylin receptor." Am J Pathol. 2011 Jan;178(1):140-9. Epub 2010 Dec 23.

Wong M, Toth J, Haney S, Krewski D, Leighton FA, Ricketts M, Westaway D, Cashman N. "PrioNet Canada: a network of centres of excellence for research on prion diseases--ongoing and future research directions." J Toxicol Environ Health A. 2011;74(2-4):73-87.

Moody, LR., Herbst, A., Aiken, JM. "Up-regulation of interferon-gamma induced genes during prion infection." Journal of Toxicology and Environmental Health, Part A 74(2) January 2011.

Daude N, Westaway D. "Biological properties of the PrP-like Shadoo protein." (pdf link) Front Biosci. 2011 Jan 1;16:1505-16.

Johnson, C.J., D. McKenzie, J.A. Pedersen and J.M. Aiken."Meat and bone meal and mineral feed additives may increase risk of oral prion disease transmission." 2010 J. Toxicol Environ Health, Part A 74(2) January 2011.

Kwai Alier, Zongming Li, David MacTavish, David Westaway and Jack H. Jhamandas "Ionic mechanisms of action of prion protein fragment, PrP(106-126), in rat basal forebrain neurons" J Neurosci Res. 2010 Aug 1;88(10):2217-27.

Jacobson KH, Lee S, Somerville RA, McKenzie D, Benson CH, Pedersen JA."Transport of the pathogenic prion protein through soils." J Environ Qual. 2010 Jul-Aug;39(4):1145-52.

Angers, R.C., H-E. Kang, D. Napier, S. Browning, T. Seward, C. Mathiason, A. Balachandran, D. McKenzie, J. Castilla, C. Soto, J. Jewell, C.G. Graham, E.A. Hoover and G.C. Telling."Prion strain mutation determined by prion protein conformational compatibility and primary structure." Science. 2010 May 28;328(5982):1111-2.

Nathalie Daude, Vivian Ng, Joel C. Watts, Sacha Genovesi, John Paul Glaves, Serene Wohlgemuth, Gerold Schmitt-Ulms, Howard Young, JoAnne McLaurin, Paul E. Fraser and David Westaway "Wild-type Shadoo proteins convert to amyloid-like forms under native conditions" J. Neurochem. 2010 Apr;113(1):92-104. Epub 2010 Jan 8.

Jennelle CS, Samuel MD, Nolden CA, Keane DP, Barr DJ, Johnson C, Vanderloo JP, Aiken JM, Hamir AN, Hoover EA."Surveillance for transmissible spongiform encephalopathy in scavengers of white-tailed deer carcasses in the chronic wasting disease area of Wisconsin" J Toxicol Environ Health A. 2009;72(17-18):1018-24.

Blanchong JA, Heisey DM, Scribner KT, Libants SV, Johnson C, Aiken JM, Langenberg JA, Samuel MD."Genetic susceptibility to chronic wasting disease in free-ranging white-tailed deer: complement component C1q and Prnp polymorphisms." Infect Genet Evol. 2009 Dec;9(6):1329-35. Epub 2009 Aug 31.

Sim VL, Caughey B. "Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils" Neurobiol Aging. 2009 Dec;30(12):2031-42

Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. "Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones" PLoS Pathog. 2009 Oct; 5(10)

Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. "Evolutionary descent of prion genes from the ZIP family of metal ion transporters" PLoS One 2009 Sep 28;4(9):e7208.

Daude N., Wohlgemuth S., Rogaeva E., Farid A.H., Heaton M. and Westaway D. "Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP". PLoS ONE, 2009 Aug 6;4(8):e6538.

Johnson CJ, Gilbert PU, McKenzie D, Pedersen JA, Aiken JM. "Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity." BMC Res Notes. 2009 Jul 6;2:121.

Moody, LR, Herbst, AJ, Yoo, HS, Vanderloo, JP, Aiken JM. "Comparative prion disease gene expression profiling using the prion disease mimetic, cuprizone" Prion 2009 Apr;3(2):99-109.

Sim VL, Caughey B. "Recent advances in prion chemotherapeutics" Infect Disord Drug Targets. 2009 Feb;9(1):81-91.

Herbst A, McIlwain S, Schmidt JJ, Aiken JM, Page CD, Li L. "Prion disease diagnosis by proteomic profiling"   J Proteome Res. 2009 Feb;8(2):1030-6.

Russo F, Johnson CJ, Johnson CJ, McKenzie D, Aiken JM, Pedersen JA. "Pathogenic prion protein is degraded by a manganese oxide mineral found in soils" J Gen Virol. 2009 Jan;90(Pt 1):275-80.