Research

Recent Prion Publications

Nathalie Daude, Vivian Ng, Joel C. Watts, Sacha Genovesi, John Paul Glaves, Serene Wohlgemuth, Gerold Schmitt-Ulms, Howard Young, JoAnne McLaurin, Paul E. Fraser and David Westaway "Wild-type Shadoo proteins convert to amyloid-like forms under native conditions" J. Neurochem 2010, In press

Kwai Alier, Zongming Li, David MacTavish, David Westaway and Jack H. Jhamandas "Ionic mechanisms of action of prion protein fragment, PrP(106-126), in rat basal forebrain neurons" J. Neuroscience Research 2010, In press

Sim VL, Caughey B. "Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils" Neurobiol Aging. 2009 Dec;30(12):2031-42

Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. "Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones" PLoS Pathog. 2009 Oct; 5(10)

Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. "Evolutionary descent of prion genes from the ZIP family of metal ion transporters" PLoS One 2009 Sep 28;4(9):e7208.

Daude N., Wohlgemuth S., Rogaeva E., Farid A.H., Heaton M. and Westaway D. "Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP". PLoS ONE, 2009 Aug 6;4(8):e6538.

Moody, LR, Herbst, AJ, Yoo, HS, Vanderloo, JP, Aiken JM. "Comparative prion disease gene expression profiling using the prion disease mimetic, cuprizone" Prion 2009 Apr;3(2):99-109.

Sim VL, Caughey B. "Recent advances in prion chemotherapeutics" Infect Disord Drug Targets. 2009 Feb;9(1):81-91.

Herbst A, McIlwain S, Schmidt JJ, Aiken JM, Page CD, Li L. "Prion disease diagnosis by proteomic profiling"   J Proteome Res. 2009 Feb;8(2):1030-6.

Russo F, Johnson CJ, Johnson CJ, McKenzie D, Aiken JM, Pedersen JA. "Pathogenic prion protein is degraded by a manganese oxide mineral found in soils" J Gen Virol. 2009 Jan;90(Pt 1):275-80.

Watts, J.C. et al. “The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections” (2007) EMBO Journal, Sep 5;26(17):4038-50.

Watts, J.C. and Westaway, D. “The prion protein family: diversity, rivalry, and dysfunction” Biochim Biophys Acta. 2007 Jun. 1772(6):654-72.

Watts, J.C., Balachandran, A.and Westaway D. “The Expanding Universe of Prion Diseases”. 2006, Public Library of Science Pathogens. 2(3) e26.